The Divine Conspiracy/The Classical Conspiracy (2007–2008)

In September 2007, Epica headlined their first tour through North America and released their third album, The Divine Conspiracy, this time on a new label, Nuclear Blast. That December, Ariën van Weesenbeek was announced to be Epica's permanent new drummer. The band toured North America again in April 2008 with Into Eternity and Symphony X, this time with Amanda Somerville because Simone had contracted a staph infection (MRSA). It was released on September 7, 2007 through Nuclear Blast in Europe. The concept that guides the songs is that God created many different religions for humanity to figure out and overcome them so as to discover that, in nature and essence, they were all in fact the same one (hence the name, "The Divine Conspiracy"). Aside from the concept of such a conspiracy, The Divine Conspiracy finalizes The Embrace That Smothers, which began in After Forever's Prison of Desire (Prologue and parts I-III) and continued in Epica's The Phantom Agony (parts IV-VI). In short, The Embrace That Smothers is a collection of 10 songs (Prologue and parts I-IX), which talks about the dangers of organized religion.

The first single of the album was released on August 10, 2007 entitled "Never Enough", accompanied by a music video and the second single, "Chasing the Dragon," was released in 2008 without an accompanying video.

On December 16, 2008, Ad Sluijter left the band. He left a message on his Myspace page with his reasoning for leaving the band, which included frustration over being unable to enjoy composing music because of deadlines. Ad's successor on guitar was announced in January 2009 to be Isaac Delahaye, who was a member of God Dethroned.

Also in 2008, Epica recorded The Classical Conspiracy, their first live album. The live show took place in Miskolc, Hungary on June 14, 2008, in the framework of the Miskolc Opera Festival (where Therion did a similar show a year before). It included a 40-piece orchestra and a 30-piece choir, and the setlist contained not only the band's songs, but also covers of classical pieces of Antonio Vivaldi, Antonín Dvořák, Giuseppe Verdi, Edvard Grieg, and of soundtracks of the movies Star Wars, Spider-Man and Pirates of the Caribbean. It was released on May 8, 2009 through Nuclear Blast Records.